Deadly Collaboration

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Deadly ingestions.

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The complement inhibitor C4b-binding protein (C4BP) prevents necrotic cells from spilling their pro-inflammatory guts, according to a study on page 1937. Trouw and colleagues now show that C4BP and its binding partner, anticoagulant protein S (PS), cooperate to grab onto necrotic cells and to inhibit the release of cellular DNA. C4BP short-circuits the complement cascade by binding to the activ...

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ژورنال

عنوان ژورنال: Science

سال: 2009

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.325_1183b